Sodium Methoxide → HCID 13105786, compound

HRID 1632497Notes

Reaction equation

HRID 1632497 reaction equation
CS[C:3]1[N:7]2[C:8]3[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=3[CH:10]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3Cl)[O:11][CH2:12][C:6]2=[N:5][N:4]=1.[CH3:25][O-:26].[Na+]>CO>[O:26]1[CH2:12][CH2:6][N:7]([C:3]2[N:7]3[C:8]4[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:9]=4[CH:10]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[O:11][CH2:12][C:6]3=[N:5][N:4]=2)[CH2:3][CH2:25]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 13068329HCID 13068329, compound

Product 1

HCID 13105786HCID 13105786, compoundYield 130%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of Compound 15 (0.76 g) prepared in Example 8-(1) in methanol (20 ml) is added sodium methoxide (0.119 g), and the mixture is stirred for 4 hours, allowed to stand overnight, and concentrated. The residue is extracted with chloroform and the extract is washed with water, dried, and concentrated. The residue is washed with ethyl acetate to give Compound 19 (0.5 g) in 66.5% yield.

Workup

  1. waitto stand overnight
  2. concentrationconcentrated
  3. extractionThe residue is extracted with chloroform
  4. washthe extract is washed with water
  5. customdried
  6. concentrationconcentrated
  7. washThe residue is washed with ethyl acetate

Sources & evidence

ORD record
ord-8b353e9e18944cfd83e8e6c30e3e4b91
Source dataset
uspto-grants-1984_10
Patent number
US04476133

Reaction notes

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