反应详情

20 g of p-acetaminobutyrophenone are suspended in 40 ml of semi-concentrated hydrochloric acid and the suspension is heated under reflux for 25 minutes and poured into a mixture of 100 ml of ice and 30 ml of concentrated sodium hydroxide solution. The mixture is filtered with suction, then the residue is washed twice with ice-cold water, dried in the atmosphere and recrystallised from methanol/water (20 ml+100 ml). p-Aminobutyrophenone having a melting point of 93°-94° is obtained.

1. temperaturethe suspension is heated
2. temperatureunder reflux for 25 minutes
3. filtrationThe mixture is filtered with suction
4. washthe residue is washed twice with ice-cold water
5. customdried in the atmosphere
6. customrecrystallised from methanol/water (20 ml+100 ml)