Water → HCID 20442972, compound

Participants

Reaction Steps

Lithium aluminium hydride (1.41 g) was added to a solution of ethyl 1-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-1H-1,2,4-triazole-3-butanoate (3.3 g) in anhydrous tetrahydrofuran (100 ml), under nitrogen, and the mixture stirred at 20° for 18 h. Successively, water (1.4 ml), 5N sodium hydroxide (1.4 ml) and water (3 ml) were added, the mixture was filtered and the filtrate evaporated to give an oil (3.1 g). The oil was chromatographed on silica using dichloromethane:ethanol:0.88 ammonia 70:8:1 as eluent to give the title compound (2.4 g) as a green oil.

Provenance & Evidence