Succinic anhydride → 2-(3-Methoxyphenyl)-5-oxo-1-phenylpyrrolidin-3-carboxylic acid

Participants

Reaction Steps

A solution of 42.3 gm. of 3-methoxybenzylidenaniline, 20 gm. of succinic anhydride and 200 ml. of xylene was refluxed for 16 hours. The crude product was obtained as a solid via the same workup used for example 1B. Recrystallization from ethyl acetate followed by a second recrystallization from acetonitrile provided 21.0 gm. of colorless crystals, m.p. 145°-149°.

Provenance & Evidence