HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 1-(3-Chlorophenyl)-3-(dimethylaminomethylene)-2(1H,3H)-indolone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 1,1-Dimethoxyethyl(dimethyl)amine | HCID 87835 | — |
| Reactant | 1-(3-Chlorophenyl)-indolin-2-one | HCID 11299530 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(3-Chlorophenyl)-3-(dimethylaminomethylene)-2(1H,3H)-indolone | HCID 53719608 | — |
Reaction Steps
By the procedure of Example A1, but substituting an equivalent of dimethylformamide dimethylacetal for the dimethylacetamide dimethylacetal, using first methylene chloride and then 7.5% ethyl acetate in methylene chloride in chromatography and recrystallization from ether-pentane, 1-(3-chlorophenyl)-2(1H,3H)-indolone (10 g, 0.041 mole) was converted to title product, 3.73 g, m.p. 116°-118°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04476307 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-a6d824a435df4cffac45dd51dc6d580a |
| Source note | uspto-grants-1984_10 |