反应详情

To a solution of 215 g of Na2CO2 in 2200 ml of water is added at room temperature a solution of 128 g of 2-hydroxyiminoacetoacetic acid-tert.butyl ester in 475 ml of methanol. 255 g of dimethyl sulphate are added, dropwise, at 8°-10°, and after 3 hours at 8°-10° and 15 hours at room temperature, the mixture is filtered. The filtrate is extracted 3 times with ethyl acetate extracted 3 times with ethyl acetate, dried over magnesium sulphate and evaporated to obtain the heading compound.

1. filtration15 hours at room temperature, the mixture is filtered
2. extractionThe filtrate is extracted 3 times with ethyl acetate
3. extractionextracted 3 times with ethyl acetate
4. dry with materialdried over magnesium sulphate
5. customevaporated
6. customto obtain the heading compound