Glycerol → HCID 13038804, compound

n-Nonanoyl chloride (23 g) was dropwise added to a stirred solution of glycerin (6.0 g) in dry pyridine (60 ml) at 0° to 5° C. over 30 minutes. The mixture was stirred at the same temperature for an hour, and then allowed to stand at room temperature overnight. The resultant mixture was poured into ice water (300 ml), and extracted with ethyl acetate (50 ml×2). The extract was washed with water (10 ml), 10% aqueous hydrochloric acid and a saturated aqueous solution of sodium chloride (40 ml) in turn, and then dried over anhydrous magnesium sulfate. The solution was evaporated in vacuo, and the residue was subjected to column chromatography on silica gel (636 g) with a mixture of chloroform and acetone (30:1). The eluate was evaporated in vacuo to give 1,3-di-n-nonanoyloxy-2-propanol, mp 30°-31° C.

1. extractionextracted with ethyl acetate (50 ml×2)
2. washThe extract was washed with water (10 ml), 10% aqueous hydrochloric acid
3. dry with materiala saturated aqueous solution of sodium chloride (40 ml) in turn, and then dried over anhydrous magnesium sulfate
4. customThe solution was evaporated in vacuo
5. additionthe residue was subjected to column chromatography on silica gel (636 g) with a mixture of chloroform and acetone (30:1)
6. customThe eluate was evaporated in vacuo

ORD record

ord-02a193697a4e41c0ae876693576bd4d4

Source dataset

uspto-grants-1984_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04477447