Water → HCID 131713931, compound

Participants

Reaction Steps

To a solution of sodium 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn isomer) (1.4 g) in N,N-dimethylformamide (40 ml) was added 3-phthalidylideneethyl bromide (1.0 g), and the mixture was stirred at ambient temperature for 15 minutes. The reaction mixture was poured into a mixture of water and ethyl acetate (each 200 ml) with stirring. The separated organic solution was washed with 5% aqueous sodium bicarbonate and then water, followed by drying over magnesium sulfate. The resultant solution was evaporated to dryness to give 2-(3-phthalidylidene)ethyl 7-[2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-cephem-4-carboxylate (syn isomer) (1.5 g), mp 150° to 156° C. (dec.).

Provenance & Evidence