Ammonium Hydroxide → S-o-nitrophenyl-L-cysteine

Participants

Reaction Steps

A solution of 71 g of S-(o-nitrophenyl)-N-acetyl-L-cysteine in 300 ml of 18M sulfuric acid and 1200 ml of water is heated to reflux for 30 min. The solution is cooled in ice and treated with 700 ml of concentrated ammonium hydroxide. The resulting solid is recrystallized from boiling water to afford S-(o-nitrophenyl)-L-cysteine; m.p. 168°-171° C.; [α]D =+67.3° (c=1.1, 1N hydrochloric acid).

Provenance & Evidence