HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-phthalimido-2,3-dihydro-1,5-benzoxazepin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-chloro-2,3-dihydro-1,5-benzoxazepin-4(5H)-one | HCID 13375156 | — |
| Reactant | Phthalimide potassium salt | HCID 24194345 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-phthalimido-2,3-dihydro-1,5-benzoxazepin-4(5H)-one | HCID 13375158 | — |
Reaction Steps
A mixture of 0.989 g of 3-chloro-2,3-dihydro-1,5-benzoxazepin-4(5H)-one and 1.0 g of potassium phthalimide in 5 ml of dimethylformamide is warmed to 90° overnight. The reaction mixture is poured into 20 ml of water and stirring is continued for 1 hr. Isolation by vacuum filtration and drying at 60° in vacuo affords 3-phthalimido-2,3-dihydro-1,5-benzoxazepin-4(5H)-one; m.p. 188°-193°; NMR (DMSO, d6) δ 7.95 (s, 4), 6.61-7.40 (m, 5), 4.92 (d of d, 1), 4.01 (d, 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04477464 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-94a31c0a37b14ddfafba65762e83e19d |
| Source note | uspto-grants-1984_10 |