反应详情

温度

25 °C

570 g of 2-nitro-4,5-dimethoxybenzyl alcohol was added over 1 hour to 733 ml of thionyl chloride at 0° C. The solution was heated to 25° C. over 2 hours and to 50°-56° C. for 2 hours. The solution was cooled to 5° C. and the mixture was poured onto 12 l of ice water with stirring. The supernatant was poured off and the solid washed with water. The oily solid was blended with ice and water, filtered, and dried in a 40° C. vacuum oven to yield 535 g, 86.4% yield.

1. temperatureThe solution was cooled to 5° C.
2. additionThe supernatant was poured off
3. washthe solid washed with water
4. filtrationfiltered
5. customdried in a 40° C. vacuum oven
6. customto yield 535 g, 86.4% yield