6-Chloro-1-(2-fluorophenyl)-1'-methylspiro[indoline-3,4'-piperidine] → 6-Chloro-1'-cyano-1-(2-fluorophenyl)spiro[indoline-3,4'-piperidine]

HRID 1632854Notes

Reaction equation

HRID 1632854 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]2[N:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[CH2:9][C:10]3([CH2:15][CH2:14][N:13]([CH3:16])[CH2:12][CH2:11]3)[C:5]2=[CH:4][CH:3]=1.C(O)(=O)/C=C\C(O)=O.ClC1C=C2[N:39](C3C=CC=CC=3F)CC3(CCN(C)CC3)C2=CC=1>>[Cl:1][C:2]1[CH:7]=[C:6]2[N:8]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:23])[CH2:9][C:10]3([CH2:15][CH2:14][N:13]([C:16]#[N:39])[CH2:12][CH2:11]3)[C:5]2=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 128016216-Chloro-1-(2-fluorophenyl)-1'-methylspiro[indoline-3,4'-piperidine]HCID 12801622HCID 12801622, compound

Product 1

HCID 131540506-Chloro-1'-cyano-1-(2-fluorophenyl)spiro[indoline-3,4'-piperidine]

Procedure

A sample of 6-chloro-1-(2-fluorophenyl)-1'-methylspiro[indoline-3,4'-piperidine], free base of Example 25, is treated according to the method of Example 25 to provide 6-chloro-1'-cyano-1-(2-fluorophenyl)spiro[indoline-3,4'-piperidine].

Sources & evidence

ORD record
ord-a23b5f0c366c401682799b85adc628e1
Source dataset
uspto-grants-1984_10
Patent number
US04477667

Reaction notes

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