p-Toluenesulfonic acid monohydrate → p-Toluenesulfonic acid

Participants

Reaction Steps

1-(2-Acetylthioethyl)-5-triphenylmethylaminomethyltetrazole, (e) (300 mg) in acetone (3 ml) was cooled to -20° and treated with p-toluenesulphonic acid monohydrate (128 mg) in acetone (2 ml). The reaction mixture was allowed to warm to room temperature and stirred for 7 hours. The resultant colourless solid was filtered off to give the p-toluenesulphonic acid salt (f) (190 mg), m.p. 184°-185°, νmax (KBr)1680, 1235, 1225, 1170, 1150, 1130, 1042, 1015, 838, 688, 572 cm-1, (D2O) 2.28 (3H,s), 2.35 (3H,s), 3.34 (2H, t, J Ca 6 Hz), 7.30 (2H, d, J 9 Hz), 7.65 (2H, d, J 9 Hz)ppm. Other signals were obscured by the HOD signal.

Provenance & Evidence