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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1632890Generated: October 26, 2026

1-Methyl-6-nitro-1H-indole → 5-(1-benzyl-5-fluoro-3-indolyl)-5-(1-methyl-6-nitro-3-indolyl)-3,4-dichloro-2(5H)-furanone

https://huagongshe.com/reaction/1632890

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-6-nitro-1H-indoleHCID 10607359—
Reactant4-(1-Benzyl-5-fluoro-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acidHCID 54289084—
Product5-(1-benzyl-5-fluoro-3-indolyl)-5-(1-methyl-6-nitro-3-indolyl)-3,4-dichloro-2(5H)-furanoneHCID 20442744—

Reaction Steps

Following a procedure similar to that described above in part B of this example by using 4-(1-benzyl-5-fluoro-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid instead of 4-(1,2-dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid and 1-methyl-6-nitroindole in place of 1,2-dimethylindole, there is obtained 5-(1-benzyl-5-fluoro-3-indolyl)-5-(1-methyl-6-nitro-3-indolyl)-3,4-dichloro-2(5H)-furanone (Formula V: R=C6H5CH2 ; R1 =R3 =H; R2 =CH3 ; Y=6-F; Y1 =6-NO2).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04477676
Source datasetuspto-grants-1984_10
ORD IDord-055f31f411d64d2e8da5e0657119279b
Source noteuspto-grants-1984_10