HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane → N-(2-chlorophenylsulfonyl)-N'-(4-difluoromethoxy-6-methylpyridin-2-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | Benzenesulfonyl isocyanate, 2-chloro- | HCID 174071 | — |
| Reactant | 4-(Difluoromethoxy)-6-methylpyrimidin-2-amine | HCID 2817390 | — |
| Product | N-(2-chlorophenylsulfonyl)-N'-(4-difluoromethoxy-6-methylpyridin-2-yl)urea | HCID 20261069 | 49.9% |
Reaction Steps
A solution of 4.9 g (0.0225 mole) of 2-chlorophenylsulfonyl isocyanate and 3.5 g (0.02 mole) of 2-amino-4-difluoromethoxy-6-methylpyrimidine in 70 ml of dioxan is stirred for 2 hours at 60°-70° C. The reaction mixture is filtered and the filtrate is concentrated. The residue is triturated with ether to give 3.8 g (49.9% of theory) of N-(2-chlorophenylsulfonyl)-N'-(4-difluoromethoxy-6-methylpyridin-2-yl)urea with a melting point of 169°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04478635 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-ba397eb2436f4cac995e066ee2e6835a |
| Source note | uspto-grants-1984_10 |