HCID 20261068, compound → Benzoic acid, 2-(isocyanatosulfonyl)-, methyl ester

HRID 1632901Notes

Reaction equation

HRID 1632901 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([NH:14][C:15]([N:17]([C:19]1[N:24]=[C:23]([O:25][CH:26]([F:28])[F:27])[CH:22]=[C:21]([O:29][CH:30]([F:32])[F:31])[N:20]=1)C)=[O:16])(=[O:13])=[O:12])=[O:4]>C(Cl)Cl>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([N:14]=[C:15]=[O:16])(=[O:12])=[O:13])=[O:4].[CH3:15][NH:17][C:19]1[N:20]=[C:21]([O:29][CH:30]([F:32])[F:31])[CH:22]=[C:23]([O:25][CH:26]([F:28])[F:27])[N:24]=1

Participants

4

Reactant 1

HCID 20261068HCID 20261068, compound

Product 2

HCID 156281Benzoic acid, 2-(isocyanatosulfonyl)-, methyl esterHCID 20261071HCID 20261071, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In the same manner as described in Example 1, 4.6 g (95.8% of theory) of N-(2-methoxycarbonylphenylsulfonyl)-N'-[4,6-bis-(difluoromethoxy)pyrimidin-2-yl]-N'-methylurea are obtained from 2.6 g (0.011 mole) of 2-methoxycarbonylphenylsulfonylisocyanate and 2.4 g (0.01 mole) of 2-methylamino-4,6-bis-(difluoromethoxy)pyrimidine in 30 ml of methylene chloride. The product melts at 114°-115° C. after recrystallisation from a mixture of acetone/ether.

Sources & evidence

ORD record
ord-9df98e7f2c9b43169bca28ec32cb3428
Source dataset
uspto-grants-1984_10
Patent number
US04478635

Reaction notes

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