Trifluoroacetic acid → HCID 131713943, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of (3S-trans)-[4-methyl-2-oxo-3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-azetidinyl]phosphonic acid, ethyl ester, potassium salt (500 mg) in anisole (5 ml) was cooled to -24° C. in an ice-methanol bath, and trifluoroacetic acid (10 ml) was added. The mixture was stirred at -24° C. to -12° C. for 3 hours, diluted with dry toluene (25 ml), and solvent was removed in vacuo at or below 19° C. The residual oil was solidified and triturated several times with ether giving 815 mg of the title compound as a powder.

Provenance & Evidence