HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 6-(Chloromethyl)-2,4(1H,3H)-pyrimidinedione | HCID 73273 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-(Aminomethyl)pyrimidine-2,4(1H,3H)-dione | HCID 312953 | — |
Reaction Steps
A mixture of 100 g (0.623 mole) of 6-chloromethylpyrimidine-2,4-dione and 200 ml of anhydrous ammonia was allowed to react overnight in a sealed bomb at about 20° C. The solid residue was slurried in ethyl acetate, and was then separated by filtration and washed sequentially with water and methanol to provide 6-aminomethylpyrimidine-2,4-dione, m.p. 295°-297° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04478835 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-5adf28619ccd4cc8b37519390f821a69 |
| Source note | uspto-grants-1984_10 |