Propylamine → HCID 20240516, compound

Participants

Reaction Steps

To a solution of 2.00 g (8.70 mmole) of 5,7-dichloro-3-isopropylimidazo[1,5-c]pyrimidine (from Example 37) in 50 ml of dioxane was added 1.15 g (19.5 mmole) of n-propylamine. The mixture was stirred for three hours. The mixture was then diluted with 75 ml of chloroform, washed with three 50 ml portions of water, dried over magnesium sulfate, and evaporated. The residue of 7-chloro-3-isopropyl-5-(n-propylamino)imidazo[1,5-c]pyrimidine was dissolved in a mixture of dioxane/diethyl ether, and hydrogen chloride gas was bubbled through. The precipitate was separated by filtration to provide white solid 7-chloro-3-isopropyl-5-(n-propylamino)imidazo[1,5-c]pyrimidine hydrochloride hydrate, m.p. 182°-184° C. Analysis: Calculated for C12H17ClN4.HCl.1/3H2O: %C, 48.8; %H, 6.4; %N, 19.0; Found; %C, 48.8; %H, 6.2; %N, 18.4.

Provenance & Evidence