Hydrochloric Acid → HCID 20279335, compound

Participants

Reaction Steps

Ethanolic potassium hydroxide (12 ml., 1M) was added to a stirred solution of spiro[pyrrolidine-3,3'-indoline]-2,2',5-trione (1.0 g.) in dimethyl sulphoxide (10 ml.). 4-Bromobenzyl bromide (1.4 g.) was then added to the clear solution which was stirred for 4 hours. This solution was then added to water (100 ml.). The mixture was acidified (concentrated hydrochloric acid). The precipitate was collected, washed with water, air-dried and recrystallised from ethyl acetate/petrol 60-80 to give 1'-(4-bromobenzyl)spiro[pyrrolidine-3,3-indoline]-2,2',5-trione (0.15 g.) m.p. 218°-220° C.

Provenance & Evidence