N-Methylbenzylamine → 8-(N-Benzyl-methylamino)-2-chloro-4-(1-oxido-thiomorpholino)pyrimido[5,4-d]pyrimidine

Participants

Reaction Steps

A solution of 12.2 gm (0.1 mol) of N-benzyl-methylamine in 50 ml of dioxane was slowly poured, while stirring, into a suspension of 15.9 gm (0.05 mol) of 2,8-dichloro-4-(1-oxido-thiomorpholino)-pyrimido[5,4-d]-pyrimidine in about 250 ml of dioxane, and the resulting mixture was heated at 30°-40° C. for about 30 minutes. The reaction mixture was taken up in about 1 liter of water, whereby the reaction product was precipitated as a slightly yellow precipitate. After standing for a little while, the precipitate was filtered off, washed with water and dried at about 60° C.

Provenance & Evidence