反应详情

20.3 gm (0.05 mol) of 8-benzylthio-2-chloro-4-(1-oxido-thiomorpholino)-pyrimido[5,4-d]pyrimidine (melting point: 188°-190° C.) were refluxed for about 45 minutes with 8 gm (0.13 mol) of 2-hydroxyethyl-amine in 400 ml of dioxane. Most of the solvent was distilled off in vacuo, and the residue was taken up in about 500 ml of water. The reaction product, which precipitated after standing for a little while, was filtered off, washed with water and dried at about 70° C.

1. distillationMost of the solvent was distilled off in vacuo
2. customThe reaction product, which precipitated
3. filtrationwas filtered off
4. washwashed with water
5. customdried at about 70° C.