Ethanolamine → 8-(N-Benzyl-methylamino)-2-(2-hydroxyethyl-amino)-4-(1-oxido-thiomorpholino)-pyrimido[5,4-d]pyrimidine

HRID 1633007Notes

Reaction equation

HRID 1633007 reaction equation
[CH2:1]([N:8]([CH3:27])[C:9]1[C:14]2[N:15]=[C:16](Cl)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22](=[O:25])[CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:28][CH2:29][CH2:30][NH2:31]>O>[CH2:1]([N:8]([CH3:27])[C:9]1[C:14]2[N:15]=[C:16]([NH:31][CH2:30][CH2:29][OH:28])[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22](=[O:25])[CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 128169948-(N-Benzyl-methylamino)-2-chloro-4-(1-oxido-thiomorpholino)pyrimido[5,4-d]pyrimidine

Product 1

HCID 130434398-(N-Benzyl-methylamino)-2-(2-hydroxyethyl-amino)-4-(1-oxido-thiomorpholino)-pyrimido[5,4-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

8.1 gm (0.02 mol) of 8-(N-benzyl-methylamino)-2-chloro-4-(1-oxido-thiomorpholino)-pyrimido[5,4-d]pyrimidine (melting point: 158°-160° C.) were heated at about 90° C. for one hour with 12.2 gm (0.2 mol) of 2-hydroxyethyl-amine. The mixture thus obtained was taken up in about 250 ml of water, whereby the reaction product separated out as a precipitate which soon solidified. It was filtered off, washed with water and dried at about 60° C. Yield: 8.2 gm (96% of theory).

Workup

  1. customThe mixture thus obtained
  2. customwhereby the reaction product separated out as a precipitate which
  3. filtrationIt was filtered off
  4. washwashed with water
  5. customdried at about 60° C

Sources & evidence

ORD record
ord-a56a1ba6e1c14c3e8e06533ee18ce6ff
Source dataset
uspto-grants-1984_10
Patent number
US04478833

Reaction notes

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