Thiomorpholine 1-oxide → 8-Benzylthio-2,4-bis-(1-oxido-thiomorpholino)-pyrimido[5,4-d]pyrimidine

HRID 1633014Notes

Reaction equation

HRID 1633014 reaction equation
[CH2:1]([S:8][C:9]1[C:14]2[N:15]=[C:16](Cl)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22](=[O:25])[CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:27]1[CH2:32][CH2:31][S:30](=[O:33])[CH2:29][CH2:28]1>O1CCOCC1>[CH2:1]([S:8][C:9]1[C:14]2[N:15]=[C:16]([N:27]3[CH2:32][CH2:31][S:30](=[O:33])[CH2:29][CH2:28]3)[N:17]=[C:18]([N:19]3[CH2:24][CH2:23][S:22](=[O:25])[CH2:21][CH2:20]3)[C:13]=2[N:12]=[CH:11][N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 12600299Thiomorpholine 1-oxideHCID 130433648-Benzylthio-2-chloro-4-(1-oxido-thiomorpholino)pyrimido[5,4-d]pyrimidine

Product 1

HCID 130435888-Benzylthio-2,4-bis-(1-oxido-thiomorpholino)-pyrimido[5,4-d]pyrimidine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

This compound was prepared analogous to Example 1 from 8-benzylthio-2-chloro-4-(1-oxido-thiomorpholino)pyrimido[5,4-d]pyrimidine (melting point: 188°-190° C.) and thiomorpholine-1-oxide by refluxing for three hours in dioxane.

Sources & evidence

ORD record
ord-152e9c184bd3429c9385b6357b7776d8
Source dataset
uspto-grants-1984_10
Patent number
US04478833

Reaction notes

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