Acetone → HCID 20441613, compound

HRID 1633079Notes

Reaction equation

HRID 1633079 reaction equation
[CH:1]1([C:5]([N:7]2[CH2:18][CH2:17][C:10]3[N:11]=[N:12][C:13]([NH:15][NH2:16])=[CH:14][C:9]=3[CH2:8]2)=[O:6])[CH2:4][CH2:3][CH2:2]1.[CH3:19][C:20]([CH3:22])=O>C(O)(=O)C>[CH:1]1([C:5]([N:7]2[CH2:18][CH2:17][C:10]3[N:11]=[N:12][C:13]([NH:15][N:16]=[C:20]([CH3:22])[CH3:19])=[CH:14][C:9]=3[CH2:8]2)=[O:6])[CH2:2][CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 180AcetoneHCID 12582653HCID 12582653, compound

Product 1

HCID 20441613HCID 20441613, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidCatalyst

Procedure

A solution of 5.8 g of 6-cyclobutanecarbonyl-3-hydrazino-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine in 50 cc of acetone and 2 drops of glacial acetic acid is heated at reflux on a water bath for 30 minutes. The crude product obtained as a brown oil is crystallized with absolute ethanol. The title compound has a M.P. of 175°-178° (decomp., from acetone/ether).

Workup

  1. temperatureat reflux on a water bath for 30 minutes

Sources & evidence

ORD record
ord-8d90e3b1e823425597395404ec7d464d
Source dataset
uspto-grants-1984_10
Patent number
US04478837

Reaction notes

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