Chloroform → HCID 12582757, compound

HRID 1633081Notes

Reaction equation

HRID 1633081 reaction equation
[C:1](O)(=O)/[CH:2]=[CH:3]/C(O)=O.[NH:9]([C:11]1[N:16]=[N:15][C:14]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:13]=2[CH:12]=1)[NH2:10].[OH-].[Na+].C(Cl)(Cl)Cl>CC(C)=O.N>[C:2](=[N:10][NH:9][C:11]1[N:16]=[N:15][C:14]2[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:13]=2[CH:12]=1)([CH3:3])[CH3:1]

Participants

6

Reactant 3

HCID 6212ChloroformHCID 14798Sodium HydroxideHCID 12582756HCID 12582756, compound

Product 1

HCID 12582757HCID 12582757, compound

Reagents, catalysts & solvents 2

HCID 222AmmoniaCatalystHCID 180AcetoneSolvent

Procedure

1.5 g of 3-hydrazino-5,6,7,8,9,10,11,12,13,14-decahydrocyclododeca[c]pyridazine fumarate are heated in 20 cc of acetone, to which a few drops of concentrated aqueous ammonia solution have been added, on a water bath for 1 hour. The mixture is cooled with ice, and the resulting crude title compound is divided between 5 cc of concentrated aqueous caustic soda solution and 20 cc of chloroform. The chloroform phase is concentrated, whereby a yellowish foam results, from which the title compound is obtained by recrystallization from absolute ethanol. M.P. 165°-166° (decomp.).

Workup

  1. additionhave been added, on a water bath for 1 hour
  2. temperatureThe mixture is cooled with ice
  3. concentrationThe chloroform phase is concentrated

Sources & evidence

ORD record
ord-bb8b2886ea5645ac8fb31ad613b3ce4e
Source dataset
uspto-grants-1984_10
Patent number
US04478837

Reaction notes

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