反应详情

A mixture composed of 19.6 g (0.05 mol) of 2-acetylamino-5-hexadecyloxyphenol, 20 g of tertbutyl chloride, 6 g of anhydrous zinc chloride and 60 ml of 1,1,1-trichloroethane was stirred with heating at a temperature range between 70° C. and 75° C. for 5 hours. After cooling, the excess amount of tert-butyl chloride and the solvent were removed under reduced pressure. The residue was washed with water and recrystallized from acetonitrile to obtain 18.2 g of 2-acetylamino-4-tert-butyl-5-hexadecyloxyphenol.

1. temperaturewith heating at a temperature range between 70° C. and 75° C. for 5 hours
2. temperatureAfter cooling
3. customthe excess amount of tert-butyl chloride and the solvent were removed under reduced pressure
4. washThe residue was washed with water
5. customrecrystallized from acetonitrile