Hydrochloric Acid → HCID 20441671, compound

Participants

Reaction Steps

A mixture of 6.39 g of 1-[2-(4-ethoxycarbonylphenylthio)ethyl]-2-(3-pyridyl)-3-methylindole in 260 ml of 2 N HCl is heated at reflux temperature for 6 hours. After cooling the pH is adjusted to 6-7 with saturated aqueopus NaHCO3 (ca 500 ml). About 200 ml of ether is added and the mixture is stirred for 0.5 hour. A solid is collected, first washed with water, then ether, and then dissolved in 100 ml hot absolute ethanol. The solution is filtered, and while still hot treated with 1.68 ml of 6.5 N ethanolic HCl. The solution is cooled and diluted with ca 100 ml ether. The resulting product is collected to yield 1-[2-(4-carboxyphenylthio)ethyl]-2-(3-pyridyl)-3-methylindole hydrochloride, m.p. 222°-224°.

Provenance & Evidence