Ethylene Glycol → HCID 15591372, compound

Participants

Reaction Steps

1-(4-Cyanobutyl)-3-methyl-2-(3-pyridyl)-indole (578 mg) is heated at 185° for 0.5 hour with 450 mg of powdered NaOH and 5 ml of ethylene glycol; there is obtained, after pouring the reaction solution into 50 ml water, washing with ether, and adjusting the pH to 6 with 2 N HCl, an oily solid which crystallizes to give 1-(4-carboxybutyl)-3-methyl-2-(3-pyridyl)indole of Example 5 (m.p. 127°-129°).

Provenance & Evidence