Hydrochloric Acid → HCID 20441658, compound

Participants

Reaction Steps

1-(4-cyanobutyl)-3-methyl-2-(3-pyridyl)indole (1.5 g) in 15 ml of ether is added to a solution of 0.0103 mole of methyl magnesium bromide in 15 ml of ether, and this mixture is heated at reflux temperature for 3 hours. After cooling, 10 ml of 6N HCl is added dropwise and this mixture refluxed for several hours. The reaction mixture is washed with ether, and basified to pH 10-11 with 3N NaOH. Ether extraction and evaporation of the solvent yields 1-(5-oxohexyl)-3-methyl-2-(3-pyridyl)- indole; IR 1720 cm-1 ; NMR (CDCl3)δ2.0.

Provenance & Evidence