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HRID1633154

反应详情

EQUATION

反应方程式

HRID 1633154 的结构方程式

REACTANTS

反应物

2
反应SMILES：CCOC(=O)CC(=O)c1cccnc1
HCID222197

ethyl 3-oxo-3-(pyridin-3-yl)propanoate

C10H11NO3

反应SMILES：CCOC(=O)CCCCCN
HCID406972

ethyl 6-aminohexanoate

C8H17NO2

PRODUCTS

产物

1
反应SMILES：CCOC(=O)C=C(NCCCCCC(=O)OCC)c1cccnc1
HCID70505436

未命名化合物

PROCEDURE

实验过程

A mixture of 196 mg of ethyl nicotinoylacetate and 192 mg of ethyl 6-aminocaproate is heated at 120°-130° under nitrogen for 18 hours. The product is purified by preparative TLC (silica gel; chloroform, ethyl acetate 9.1) to yield ethyl β-(3-pyridyl)-β-(5-ethoxycarbonylpentylamino)acrylate;Rf =0.3.

WORKUP

后处理

  1. temperatureis heated at 120°-130° under nitrogen for 18 hours
  2. customThe product is purified by preparative TLC (silica gel; chloroform, ethyl acetate 9.1)