Ethyl 3-oxo-3-(pyridin-3-yl)propanoate → HCID 70505436, compound

HRID 1633154Notes

Reaction equation

HRID 1633154 reaction equation
[C:1]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[NH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([C:1]([NH:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])=[CH:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:3]=1

Participants

3

Reactant 2

HCID 222197Ethyl 3-oxo-3-(pyridin-3-yl)propanoateHCID 406972ethyl 6-aminohexanoate

Product 1

HCID 70505436HCID 70505436, compound

Procedure

A mixture of 196 mg of ethyl nicotinoylacetate and 192 mg of ethyl 6-aminocaproate is heated at 120°-130° under nitrogen for 18 hours. The product is purified by preparative TLC (silica gel; chloroform, ethyl acetate 9.1) to yield ethyl β-(3-pyridyl)-β-(5-ethoxycarbonylpentylamino)acrylate;Rf =0.3.

Workup

  1. temperatureis heated at 120°-130° under nitrogen for 18 hours
  2. customThe product is purified by preparative TLC (silica gel; chloroform, ethyl acetate 9.1)

Sources & evidence

ORD record
ord-2e4ec8d7e7ad4111a6cccd5e195a7246
Source dataset
uspto-grants-1984_10
Patent number
US04478842

Reaction notes

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