HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid ethylester 1,1-dioxide → Piroxicam
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid ethylester 1,1-dioxide | HCID 54679348 | — |
| Reactant | HCID 178508381 | HCID 178508381 | — |
| Product | Piroxicam | HCID 54676228 | — |
Reaction Steps
The process of claim 1, wherein ethyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide of formula (V) is reacted with 2-amino-pyridyl-magnesium bromide of formula (VI) to give 4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04478996 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-3ddb8ef94a5549529dd93f7c38d82eca |
| Source note | uspto-grants-1984_10 |