P-Anisidine → 5,6-Dichloro-3-[(4-methoxyphenyl)imino]methylpyrazinamine

Participants

Reaction Steps

In a manner similar to that described in Example 9, 1.92 grams (0.01 mole) of 3-amino-5,6-dichloropyrazinaldehyde, 1.23 g (0.01 mole) of p-anisidine and 15 milliliters of ethanol were mixed together and heated at reflux temperature to obtain a 5,6-dichloro-3-[(4-methoxyphenyl)imino]methylpyrazinamine product which precipitated in the reaction mixture. The product was recovered by filtration, recrystallized from ethanol to obtain 2.14 grams of a purified product, m.p. 167°-168° C. (dec). Elemental analyses were as follows:

Provenance & Evidence