HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1633244Generated: October 31, 2026
Morpholine → 3-Acetyl-2-[2-[3-(morpholinocarbonyl)propoxy]phenyl]benzothiazoline
https://huagongshe.com/reaction/1633244
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Isobutyl chloroformate | HCID 62365 | — |
| Reactant | 3-Acetyl-2-[2-[3-(carboxy)propoxy]phenyl]benzothiazoline | HCID 13335900 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Acetyl-2-[2-[3-(morpholinocarbonyl)propoxy]phenyl]benzothiazoline | HCID 13335901 | — |
Reaction Steps
To the solution of 1.79 g of 3-acetyl-2-[2-[3-(carboxy)-propoxy]phenyl]benzothiazoline and 0.51 g of triethylamine in 20 ml of anhydrous methylene chloride, 0.68 g of isobutyl chloroformate is added dropwise while stirring at -13° C. and stirred additional 10 minutes at the same temperature. To the solution 0.44 g of morpholine in 5 ml of methylene chloride is added dropwise.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04479949 |
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| Source dataset | uspto-grants-1984_10 |
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| ORD ID | ord-2d50ad302c6d4c75b1505e440b8cb779 |
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| Source note | uspto-grants-1984_10 |
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