N-(2,6-dimethylphenyl)-ethylenediamine → 1-(1H-Indazol-4-yloxy)-3-((2-(2,6-xylidino)ethyl)amino)-2-propanol

Participants

Reaction Steps

6.2 g. 2-Benzyl-4-(2,3-epoxypropoxy)-indazole and 7.2 g. 2-(2,6-dimethylphenylamino)-ethylamine are stirred for 20 hours at 70° C. The reaction mixture is then dissolved in methylene chloride and purified chromatographically over a silica gel column using methylene chloride/methanol (saturated with ammonia) (20:1 v/v) as elution agent. After evaporation, the desired compound is obtained in the form of a viscous oil in a yield of 6.8 g. (69% of theory).

Provenance & Evidence