Phosgene → HCID 178424800, compound

Participants

Reaction Steps

Phosgene is passed into a solution of 21.5 g. 2,3-diamino-1-{2-hydroxy-3-[2-(2,6-dimethylphenylamino)-ethylamino]-propoxy}-benzene trihydrochloride in 400 ml. water for 45 minutes, while cooling (internal temperature 20° to 25° C.). After flushing with nitrogen, the aqueous supernatant is decanted off and the precipitate recrystallized from ethanol/methanol (1:1 v/v), with the addition of active charcoal. There are obtained 6.6 g. (35% of theory) of the desired compound; m.p. 248°-250° C.

Provenance & Evidence