HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(Benzyloxycarbonyl)-D-phenylalanine → 1-(6-Benzoylamino-9H-purin-9-yl)-1,3-dideoxy-3-(N-benzyloxycarbonyl-D-phenylalanylamino)-beta-D-ribofuranuronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(Benzyloxycarbonyl)-D-phenylalanine | HCID 675678 | — |
| Reactant | 3-amino-1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-beta-D-ribofuranuronic acid | HCID 53854008 | — |
| Product | 1-(6-Benzoylamino-9H-purin-9-yl)-1,3-dideoxy-3-(N-benzyloxycarbonyl-D-phenylalanylamino)-beta-D-ribofuranuronic acid | HCID 70466093 | 60.9% |
Reaction Steps
1-(6-Benzoylamino-9H-purin-9-yl)-1,3-dideoxy-3-(N-benzyloxycarbonyl-D-phenylalanylamino)-β-D-ribofuranuronic acid (405 mg) was prepared by reacting 1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-3-amino-β-D-ribofuranuronic acid (384 mg) prepared in Example 1 with N-hydroxysuccinimide ester of N-benzyloxycarbonyl-D-phenylalanine (543 mg) according to a similar manner to that of Example 5, mp. 206°-210° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04479942 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-4f5ba89c982f495294829cc82313c4be |
| Source note | uspto-grants-1984_10 |