2-((tert-Butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid → 1-(6-Benzoylamino-9H-purin-9-yl)-3-[N-tert-butoxycarbonyl-beta-(4-fluorophenyl)-D,L-alanylamino]-1,3-dideoxy-beta-D-ribofuranuronic acid

Participants

Reaction Steps

1-(6-Benzoylamino-9H-purin-9-yl)-3-[N-tert-butoxycarbonyl-β-(4-fluorophenyl)-D,L-alanylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (575 mg) was prepared by reacting 1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-3-amino-β-D-ribofuranuronic acid (384 mg) prepared in Example 1 with N-hydroxysuccinimide ester of N-tert-butoxycarbonyl-β-(4-fluorophenyl)-D,L-alanine (417 mg) according to a similar manner to that of Example 5, mp. 125°-134° C. (dec.).

Provenance & Evidence