N2,N6-Bis[(phenylmethoxy)carbonyl]-L-lysine → 1-(6-Benzoylamino-9H-purin-9-yl)-3-(Nalpha,Nepsilon-dibenzyloxycarbonyl-L-lysylamino)-1,3-dideoxy-beta-D-ribofuranuronic acid

Participants

Reaction Steps

1-(6-Benzoylamino-9H-purin-9-yl)-3-(Nα,Nε -dibenzyloxycarbonyl-L-lysylamino)-1,3-dideoxy-β-D-ribofuranuronic acid (420 mg) was prepared by reacting 1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-3-amino-β-D-ribofuranuronic acid (384 mg) prepared in Example 1 with N-hydroxysuccinimide ester of Nα,Nε -dibenzyloxycarbonyl-L-lysine (608 mg) according to a similar manner to that of Example 5, mp. 150°-157° C. (dec.).

Provenance & Evidence