HuagongsheHuagongshe Chemistry Print Report · For research reference only
Z-Tyr(Bzl)-OH → 1-(6-Benzoylamino-9H-purin-9-yl)-3-(N-benzyloxycarbonyl-O-benzyl-L-tyrosylamino)-1,3-dideoxy-beta-D-ribofuranuronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Z-Tyr(Bzl)-OH | HCID 47600 | — |
| Reactant | 3-amino-1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-beta-D-ribofuranuronic acid | HCID 53854008 | — |
| Product | 1-(6-Benzoylamino-9H-purin-9-yl)-3-(N-benzyloxycarbonyl-O-benzyl-L-tyrosylamino)-1,3-dideoxy-beta-D-ribofuranuronic acid | HCID 70465277 | 52.3% |
Reaction Steps
1-(6-Benzoylamino-9H-purin-9-yl)-3-(N-benzyloxycarbonyl-O-benzyl-L-tyrosylamino)-1,3-dideoxy-β-D-ribofuranuronic acid (210 mg) was prepared by reacting 1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-3-amino-β-D-ribofuranuronic acid (200 mg) prepared in Example 1 with N-hydroxysuccinimide ester of N-benzyloxycarbonyl-O-benzyl-L-tyrosine (260 mg) according to a similar manner to that of Example 5, mp. 150°-155° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04479942 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-d973a0f8c4594663911a4dc312454da3 |
| Source note | uspto-grants-1984_10 |