反应详情

A mixture of 1-(6-benzoylamino-9H-purin-9yl)-1,3-dideoxy-3-(N-benzyloxycarbonyl-L-phenylalanylamino)-β-D-ribofuranuronic acid (432 mg) prepared in Example 5 and n-butylamine (3.5 ml) in methanol (15 ml) was refluxed for 50 minutes and evaporated to dryness. The residue was dissolved in a mixture of water and diethyl ether and the aqueous layer was separated out. The aqueous solution was adjusted to pH 4 to 5 with 10% hydrochloric acid and the resulting precipitates were collected by filtration, washed with water and dried to give 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-(N-benzyloxycarbonyl-L-phenylalanylamino)-β-D-ribofuranuronic acid (267 mg), mp. 195°-201° C. (dec.).

1. temperaturewas refluxed for 50 minutes
2. customevaporated to dryness
3. dissolutionThe residue was dissolved in a mixture of water and diethyl ether
4. customthe aqueous layer was separated out
5. customthe resulting precipitates
6. filtrationwere collected by filtration
7. washwashed with water
8. customdried