Butylamine → HCID 476145, compound

HRID 1633292Notes

Reaction equation

C([NH:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[C@@H:19]1[O:24][C@H:23]([C:25]([OH:27])=[O:26])[C@@H:22]([NH:28][C:29](=[O:37])[CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C@H:20]1[OH:21])(=O)C1C=CC=CC=1.C(N)CCC>>[NH2:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[C@@H:19]1[O:24][C@H:23]([C:25]([OH:27])=[O:26])[C@@H:22]([NH:28][C:29](=[O:37])[CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C@H:20]1[OH:21]

Participants

Reactant 2

HCID 8007Butylamine

HCID 53672265HCID 53672265, compound

Product 1

HCID 476145HCID 476145, compoundYield 36%

Procedure

1-(6-Amino-9H-purin-9-yl)-3-(phenylacetylamino)-1,3-dideoxy-β-D-ribofuranuronic acid (97 mg) was prepared by reacting 1-(6-benzoylamino-9H-purin-9-yl)-3-(phenylacetylamino-1,3-dideoxy-β-D-ribofuranuronic acid (340 mg) prepared in Example 17 with n-butylamine according to a similar manner to that of Example 23, mp. 159°-165° C. (dec.).

Sources & evidence

ORD record: ord-499441b200c84d5e8c1ec1eb91e3a258
Source dataset: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04479942

Reaction notes

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