HRID1633299

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8007

Butylamine

C4H11N

反应SMILES：O=C(N[C@H](Cc1ccccc1)C(=O)N[C@H]1[C@@H](O)[C@H](n2cnc3c(NC(=O)c4ccccc4)ncnc32)O[C@@H]1C(=O)O)OCc1ccccc1

HCID70466093

未命名化合物

PRODUCTS

产物

反应SMILES：Nc1ncnc2c1ncn2[C@@H]1O[C@H](C(=O)O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)OCc2ccccc2)[C@H]1O

HCID70466052

未命名化合物

收率 65.5%

PROCEDURE

实验过程

1-(6-Amino-9H-purin-9-yl)-1,3-dideoxy-3-(N-benzyloxycarbonyl-D-phenylalanylamino)-β-D-ribofuranuronic acid (199 mg) was prepared by reacting 1-(6-benzoylamino-9H-purin-9-yl)-1,3-dideoxy-3-(N-benzyloxycarbonyl-D-phenylalanylamino)-β-D-ribofuranuronic acid (360 mg) prepared in Example 6 with n-butylamine (3 ml) according to a similar manner to that of Example 23, mp. 196°-202° C. (dec.).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-945a9241f9dd45b38a9a2f851db85027
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US04479942
来源说明: uspto-grants-1984_10

反应SMILES

C([NH:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[C@@H:19]1[O:24][C@H:23]([C:25]([OH:27])=[O:26])[C@@H:22]([NH:28][C:29](=[O:49])[C@@H:30]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[NH:31][C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])[C@H:20]1[OH:21])(=O)C1C=CC=CC=1.C(N)CCC>>[NH2:9][C:10]1[N:18]=[CH:17][N:16]=[C:15]2[C:11]=1[N:12]=[CH:13][N:14]2[C@@H:19]1[O:24][C@H:23]([C:25]([OH:27])=[O:26])[C@@H:22]([NH:28][C:29](=[O:49])[C@@H:30]([CH2:42][C:43]2[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=2)[NH:31][C:32]([O:34][CH2:35][C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=2)=[O:33])[C@H:20]1[OH:21]