Ammonia → 1-(6-amino-9H-purin-9-yl)-3-amino-1,3-dideoxy-beta-D-ribofuranuronic acid

Participants

Reaction Steps

A mixture of 1-(6-benzoylamino-9H-purin-9-yl)-3-amino-1,3-dideoxy-β-D-ribofuranuronic acid (1.0 g) prepared in Example 1, concentrated aqueous ammonia (16 ml) and methanol (8 ml) was refluxed for 1.75 hours. The reaction mixture was evaporated to dryness and the residue was triturated in methanol (20 ml) to give 1-(6-amino-9H-purin-9-yl)-3-amino-1,3-dideoxy-β-D-ribofuranuronic acid (554 mg), mp. 245°-249° C. (dec.).

Provenance & Evidence