1-(6-Amino-9H-purin-9-yl)-3-[N-tert-butoxycarbonyl-beta-(4-fluorophenyl)-D,L-alanylamino]-1,3-dideoxy-beta-D-ribofuranuronic acid → 3-[2-Amino-3-(4-fluorophenyl)propanoylamino]-5-(6-aminopurin-9-yl)-4-hydroxyoxolane-2-carboxylic acid

Participants

Reaction Steps

1-(6-Amino-9H-purin-9-yl)-3-[β-(4-fluorophenyl)-D,L-alanylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (173 mg) was prepared by reacting 1-(6-amino-9H-purin-9-yl)-3-[N-tert-butoxycarbonyl-β-(4-fluorophenyl)-D,L-alanylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (320 mg) prepared in Example 27 and formic acid (5 ml) according to a similar manner to that of Example 45, mp. 120°-130° C. (dec.).

Provenance & Evidence