Butylamine → N-[5-(6-Aminopurin-9-yl)-2-(N-butylcarbamoyl)-4-hydroxyoxolan-3-yl]-2-[(butylamino)carbonylamino]-3-(4-methoxyphenyl)propanamide

Participants

Reaction Steps

A mixture of methyl 1-(6-benzoylamino-9H-purin -9-yl)-1,3-dideoxy-3-(N-benzyloxycarbonyl-O-methyl-L-tyrosylamino)-β-D-ribofuranuronate prepared in Example 56 (355 mg), n-butylamine (5 ml) and methanol (5 ml) was refluxed for 9 hours. The mixture was evaporated to dryness and the residue was triturated in diethyl ether to give N-n-butyl-1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-(N-n-butylcarbamoyl-O-methyl-L-tyrosylamino)-β-D-ribofuranuronamide (208 mg), mp. 111°-115° C. (dec.).

Provenance & Evidence