HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-((tert-Butoxycarbonyl)amino)-3-(3-chlorophenyl)propanoic acid → Methyl 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-[N-tert-butoxycarbonyl-beta-(3-chlorophenyl)-D,L-alanylamino]-beta-D-ribofuranuronate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-((tert-Butoxycarbonyl)amino)-3-(3-chlorophenyl)propanoic acid | HCID 6915684 | — |
| Reactant | HCID 54526695 | HCID 54526695 | — |
| Product | Methyl 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-[N-tert-butoxycarbonyl-beta-(3-chlorophenyl)-D,L-alanylamino]-beta-D-ribofuranuronate | HCID 22828234 | 54.2% |
Reaction Steps
Methyl 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-[N-tert-butoxycarbonyl-β-(3-chlorophenyl)-D,L-alanylamino]-β-D-ribofuranuronate (312 mg) was prepared by reacting methyl 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-amino-β-D-ribofuranuronate (294 mg) prepared in Example 62 with N-tert-butoxycarbonyl-β-(3-chlorophenyl)-D,L-alanine (300 mg) according to a similar manner to that of Example 64, mp. 115°-125° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04479942 |
| Source dataset | uspto-grants-1984_10 |
| ORD ID | ord-554dcad4e03d4ab998069ffc54fa420e |
| Source note | uspto-grants-1984_10 |