HRID1633315

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@H](Cc1ccccc1)C(=O)O

HCID637610

Boc-D-phenylalanine

C14H19NO4

结构：COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N)ncnc43)O[C@@H]2C(=O)O)cc1.Cl.Cl.O

HCID70466244

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N)ncnc43)O[C@@H]2C(=O)O)cc1

HCID22828222

未命名化合物

收率 89.6%

PROCEDURE

实验过程

1-(6-Amino-9H-purin-9-yl)-3-[N-(N-tert-butoxycarbonyl-β-phenyl-D-alanyl)-O-methyl-L-tyrosylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (488 mg) was prepared by reacting 1-(6-amino-9H-purin-9-yl)-1,3-dideoxy-3-(O-methyl-L-tyrosylamino)-β-D-ribofuranuronic acid dihydrochloride monohydrate (424 mg) prepared in Example 4 with N-hydroxysuccinimide ester of N-tert-butoxycarbonyl-β-phenyl-D-alanine (290 mg) according to a similar manner to that of Example 5, mp. 164°-168° C. (dec.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c0ed5be1f4f44a9da805e202c6bb95aa
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04479942
来源说明: uspto-grants-1984_10

反应 SMILES

O.Cl.Cl.[NH2:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[C@@H:14]1[O:19][C@H:18]([C:20]([OH:22])=[O:21])[C@@H:17]([NH:23][C:24](=[O:36])[C@H:25]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[NH2:26])[C@H:15]1[OH:16].[C:37]([O:41][C:42]([NH:44][C@@H:45]([C:53](O)=[O:54])[CH2:46][C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1)=[O:43])([CH3:40])([CH3:39])[CH3:38]>>[NH2:4][C:5]1[N:13]=[CH:12][N:11]=[C:10]2[C:6]=1[N:7]=[CH:8][N:9]2[C@@H:14]1[O:19][C@H:18]([C:20]([OH:22])=[O:21])[C@@H:17]([NH:23][C:24](=[O:36])[C@H:25]([CH2:27][C:28]2[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=2)[NH:26][C:53](=[O:54])[C@@H:45]([CH2:46][C:47]2[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=2)[NH:44][C:42]([O:41][C:37]([CH3:40])([CH3:38])[CH3:39])=[O:43])[C@H:15]1[OH:16]