HRID1633316

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(C[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)OC(C)(C)C)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N)ncnc43)O[C@@H]2C(=O)O)cc1

HCID22828222

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C[C@H](NC(=O)[C@H](N)Cc2ccccc2)C(=O)N[C@H]2[C@@H](O)[C@H](n3cnc4c(N)ncnc43)O[C@@H]2C(=O)O)cc1

HCID22828221

未命名化合物

收率 66.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID284

Formic acid

CH2O2

PROCEDURE

实验过程

1-(6-Amino-9H-purin-9-yl)-1,3-dideoxy-3-[N-(β-phenyl-D-alanyl)-O-methyl-L-tyrosylamino]-β-D-ribofuranuronic acid (240 mg) was prepared by reacting 1-(6-amino-9H-purin-9-yl)-3-[N-(N-tert-butoxycarbonyl-β-phenyl-D-alanyl-O-methyl-L-tyrosylamino]-1,3-dideoxy-β-D-ribofuranuronic acid (420 mg) prepared in Example 84 with formic acid (6.7 ml) according to a similar manner to that of Example 45, mp. 175°-182° C. (dec.).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-816ed88345184866b13f0955755956fe
来源数据集: uspto-grants-1984_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04479942
来源说明: uspto-grants-1984_10

反应 SMILES

[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([OH:19])=[O:18])[C@@H:14]([NH:20][C:21](=[O:51])[C@H:22]([CH2:42][C:43]2[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][CH:44]=2)[NH:23][C:24](=[O:41])[C@@H:25]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:26]C(OC(C)(C)C)=O)[C@H:12]1[OH:13]>C(O)=O>[NH2:1][C:2]1[N:10]=[CH:9][N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[C@@H:11]1[O:16][C@H:15]([C:17]([OH:19])=[O:18])[C@@H:14]([NH:20][C:21](=[O:51])[C@H:22]([CH2:42][C:43]2[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][CH:44]=2)[NH:23][C:24](=[O:41])[C@@H:25]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH2:26])[C@H:12]1[OH:13]