Methyl Chloride → HCID 178493584, compound

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Reaction Steps

19.2 g of 2-amino-4,6-dimethoxy-pyrimidine hydrochloride are heated at 150° C. for 2 hours, in the course of which methyl chloride is removed and 2-amino-4-hydroxy-6-methoxy-pyrimidine is formed. After the addition of 80 ml of 40% sodium hydroxide solution and 100 ml of dioxane, there are introduced at 70° to 75° C., during 45 minutes, 22 g of difluorochloromethane. The organic phase is then separated, concentrated to about 1/5 of its volume and poured into water, and the solid precipitate is removed. The yield is 2.4 g of 2-amino-4-difluoromethoxy-6-methoxy-pyrimidine, m.p. 106° to 107° C. (compound No. 1.7).

Provenance & Evidence